KMID : 1036920230280040267
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Annals of Pediatric Endocrinology & Metabolism 2023 Volume.28 No. 4 p.267 ~ p.274
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Association of birth weight with risk of diabetes mellitus in adolescence and early adulthood: analysis of the Indonesian Family Life Survey
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Ratu Ayu Dewi Sartika
Fathimah Sulistyowati Sigit Edy Purwanto Norliyana Aris Avliya Quratul Marjan Wahyu Kurnia Yusrin Putra Sutanto Priyo Hastono
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Abstract
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Purpose: We aimed to investigate the association of birth weight with the risk of diabetes mellitus in adolescence and early adulthood in the Indonesian population.
Methods: This study analyzed data from the Indonesian Family Life Survey, a longitudinal study of the Indonesian population with repeated measurements at 3 time points (1997, 2007, and 2014). The subjects observed were children aged 0?59 months in 1997, who were 10?15 years old in 2007, and 17?22 years in 2014. We performed a generalized linear model to investigate the association between birth weight at baseline and the level of hemoglobin A1c (HbA1c) at the 2 follow-up periods. We adjusted the association for the characteristics of the children, parents, and household.
Results: The mean¡¾standard deviation level of HbA1c was 7.35%¡¾0.95% in 2007 and decreased to 5.30%¡¾0.85% in 2014. The crude ¥â (95% confidence interval [CI]) of the association between birth weight and HbA1c was 0.150 (-0.076, 0.377) in 2007 and 0.146 (-0.060, 0.351) in 2014. After adjustment for the sociodemographic characteristics of the children, parents, and confounding factors, the adjusted ¥â (95% CI) was 1.12 (0.40?1.85) in 2007 and 0.92 (0.35?1.48) in 2014. The HbA1c of the parents, father¡¯s employment status, percentage of food expenditure, and underweight were the covariates that had significant associations with HbA1c.
Conclusion: HbA1c level was higher in adolescence than in early adulthood. Birth weight was associated with HbA1c level in both periods. The HbA1c of the parents, father¡¯s employment, percentage of food expenditure, and underweight partly explained the association between birth weight and the HbA1c level.
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KEYWORD
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Birth weight, Diabetes mellitus, Adolescence, Early adulthood, Hemoglobin A1c, Cohort
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